CRP was significantly associated with AMD across all three models: non-adjusted [1.23 (1.08∼1.40), p = 0.012], adjusted by age, gender, and race [1.23 (01.05∼1.42), p = 0.005], and adjusted by all covariates [ 1.24 (1.07∼1.44), p = 0.005], showing a significant correlation with AMD. This evidence concerns the gene CRP and age-related macular degeneration.