APOA1 and age-related macular degeneration: A previous studies show that higher levels of certain lipids like high-density lipoprotein cholesterol (HDL-C) and apolipoprotein a1 (ApoA1) increase the risk for all types of AMD, while lower levels of other lipids, notably low-density lipoprotein cholesterol (LDL-C) and ApoB, along with triglycerides (TG), are linked to a lower risk for specific AMD subtypes, a finding that holds up even after accounting for lipid interactions [13].