According to the ATC classification system, and as shown in Table 2, most patients were administered drugs for acid related disorders (including antacids and drugs for peptic ulcer and gastro-oesophageal reflux disease [GORD]) (50%, N = 277); agents acting on the renin-angiotensin system (41%, N = 227); and lipid modifying agents (HMG CoA reductase inhibitors were included) (31%, N = 173); psycholeptics (30%, N = 165); analgesics (including opioids and antipyretics) (29%, N = 162), and drugs for diabetes mellitus (20%, N = 108). The gene discussed is HMGCR; the disease is gastroesophageal reflux disease.