Moreover, in lung adenocarcinoma (LUAD) driven by B-Raf proto-oncogene (BRAF), reducing Cu levels inhibited the initiation of ULK-dependent autophagy, thereby bolstering the antitumor efficacy of traditional MAPK pathway inhibitors that induced the upregulation of protective autophagy [104]. The gene discussed is BRAF; the disease is lung adenocarcinoma.