GDE2 intracellular accumulation and impaired GPI-anchored protein release are also detected in ALS and ALS/FTD (Westerhaus et al, 2022), where TDP-43 pathologies are prominent, but the role of GDE2 in ALS and ALS/FTD disease pathology is unknown. The gene discussed is GDPD5; the disease is amyotrophic lateral sclerosis.