TARDBP and amyotrophic lateral sclerosis: Abnormalities in the RNA/DNA-binding protein TDP-43 (transactive response DNA-binding protein of 43 kD) are associated with neurodegeneration across multiple neurodegenerative diseases that include amyotrophic lateral sclerosis (ALS), ALS-frontotemporal dementia (FTD), and Alzheimer’s disease (AD) (Kim and Taylor, 2017; Ling et al, 2013; Tziortzouda et al, 2021).