NUP98 and frontotemporal dementia: Further, aberrant Nup98 cytoplasmic localization and aggregates are observed in neurodegenerative diseases such as ALS, ALS/FTD, and AD (Coyne et al, 2020; Eftekharzadeh et al, 2018; Hutten and Dormann, 2020; Moore et al, 2020).