FUS and amyotrophic lateral sclerosis: The use of iSNs from patient iPSCs has helped address some of these difficulties, showing that Wnt signaling is elevated in C9ALS iSNs and in iSNs containing ALS-associated mutations in FUS (fused in sarcoma), and contributes to decreased synaptic protein numbers and cell death respectively (Chen et al, 2023; Hawkins et al, 2022).