Interestingly, in the absence of infection, we observed endogenous proteolysis of proteins known to be cleaved by enteroviruses, including DDX6 (Saeed et al, 2020), HNRPM (Jagdeo et al, 2015), EIF5B (de Breyne et al, 2008), G3BP1 (Zhang et al, 2018), and eIF4G1/2 (Etchison et al, 1982). This evidence concerns the gene DDX6 and infection.