Similar to previous results obtained from Bmal1IEC−/− mice [11], intestinal clock-controlled taxa involved in SCFA fermentation and secondary bile acid formation lost rhythmicity in IL-10−/−Sv129 mice and thereby likely caused arrhythmicity in the levels of specific BAs, such as DCA, 7-sulfo CA, HDCA and α-MCA, which have frequently been linked to intestinal inflammation [37]. The gene discussed is CLOCK; the disease is inflammation.