Consistently, according to the pathohistological evaluation, CD4+ T-cell recruitment and colonic Tnf expression were greater than the control levels in IL-10−/−BL6 mice under RF conditions (histology: p = 0.0138, CD4 cell recruitment: p = 0.0069, TNF expression: p = 0.0404) but remained indistinguishable between AD and RF conditions in Bmal1IEC−/−xIL-10−/−BL6 mice (histology: p = 0.7718, CD4 + T-cell recruitment: P = 0.6826, TNF expression: P = 0.7619; Fig. 6H–K), suggesting that the intestinal clock gates the beneficial effect of RF. Here, CD4 is linked to Alzheimer disease.