GBA1 and Parkinson disease: To investigate if the individual and combined effects of the lifestyle factors coffee, tobacco, and aspirin are exclusive to idiopathic PD or if these effects can also be found in patients who carry GBA1 variants, which are considered some of the strongest genetic risk variants for PD, we examined the relationship between the protective lifestyle factors and AAO in an additional study group of patients with GBA1-PD from Fox Insight.