In a typical inflammatory response model, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are produced first, followed by an increase in interleukin-2 (IL-2) and interleukin-1α (IL-1α), which may lead to leukocytosis due to neutrophilia in the systemic circulation and immunosuppression4. The gene discussed is TNF; the disease is Increased total leukocyte count.