The CCK-8 assay showed that, in SW480 and HCT116 colon cancer cells, OXA combined with 10 μM CAPE reduced the IC50 of OXA from 14.24 ± 1.03 and 84.16 ± 3.02 μM to 2.11 ± 0.15 and 3.92 ± 0.17 μM, respectively (Fig. 1d). Here, SMC2 is linked to malignant colon neoplasm.