HGPS, a progeroid laminopathy, is caused by a point mutation in the LMNA gene that results in the production of progerin, a truncated form of the nuclear protein lamin A. At the molecular level, progerin causes numerous senescence-associated responses such as genomic instability, DNA damage and nuclear deformation and as such affects multiple ageing-related processes such as mTOR signaling, inflammation, microRNA activation, and stress response mechanisms (Cenni et al, 2020). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.