MCL1 and B-cell chronic lymphocytic leukemia: As resistance to apoptosis is a hallmark of CLL-B clonal lymphocytes, characterized by elevated expression of anti-apoptotic BCL-2 family proteins [34], we measured the expression levels of BCL-2 and MCL-1 genes, which encode anti-apoptotic proteins, in CLL-B-cells incubated with EVs from M2-THP1 cells or NLCs (Fig. 2C, D).