Another article highlights the relationship between SPEN mutations and CLL, the study reveals that SPEN mutations are present in 4% of high-risk CLL cases, impacting the NOTCH1 signaling pathway through the derepression of NOTCH1 target genes such as HES1, DTX1, and MYC [68]. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.