Among the upregulated genes, we notably found RGS1 and DAD1. RGS1 has been found to be upregulated in several cancers, it is an unfavorable prognostic marker in renal and stomach cancer [58], high immunohistochemical expression of RGS1 has also been linked to poor overall survival in diffuse large B cell lymphoma (DLBCL) patients [59]. Here, RGS1 is linked to gastric cancer.