TP53 and B-cell chronic lymphocytic leukemia: Furthermore, a study by Samuel et al. describes that a 30- to 40-fold induction of wild-type p53 protein was observed in 50 distinct human CLL patients tested, without the induction of either cell-cycle arrest or apoptosis, however, the mRNA levels for p53 did not increase, indicating that its elevation occurred post-transcriptionally [57].