We showed that EVs derived from NLCs, as well as their in vitro model equivalent, M2-polarized THP1 cells, protect CLL-B-cells from apoptosis and enhance their proliferation ex vivo compared to EVs derived from healthy monocytes, notably through the overexpression of anti-apoptotic gene BCL-2 and proliferation-inducing gene APRIL. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.