As use cases, the literature-derived CNS HDAC6 network was integrated with gene expression profiles of three common brain-related disorders: Alzheimer’s disease (AD) (GSE36980)30, Parkinson’s disease (PD) (GSE20292)31, and amyotrophic lateral sclerosis (ALS) (GSE76220)32. The gene discussed is HDAC6; the disease is amyotrophic lateral sclerosis.