In order to reveal the relationship between IDH1 mutation, tumour grade and PTBP1 expression, TCGA LGG sample cohort, CGGA mRNA_325, CGGA mRNA_301, CGGA mRNA_693 sample cohort were used to compare the difference in PTBP1 expression between IDH1 mutant and wild type, and different tumour grades of glioma patients with PTBP1 expression in patients. This evidence concerns the gene PTBP1 and neoplasm.