By comparing the expression of PTBP1 mRNA in each tumor sample with the expression of DNA mismatch repair genes (MMRs) and the expression of methyltransferase-related genes, we found that mismatch repair-related genes and methyltransferase-related genes were found to be significantly positively correlated with PTBP1 expression in most cancers. The gene discussed is PTBP1; the disease is cancer.