In order to reveal the relationship between IDH1 mutation, tumour grade and PTBP1 expression, TCGA LGG sample cohort, CGGA mRNA_325, CGGA mRNA_301, CGGA mRNA_693 sample cohort were used to compare the difference in PTBP1 expression between IDH1 mutant and wild type, and different tumour grades of glioma patients with PTBP1 expression in patients. The gene discussed is PTBP1; the disease is central nervous system cancer.