CHL1 and type 2 diabetes mellitus: For example, we observed strong correlations between DNA methylation of several CpG sites and gene expression of SLC2A2, CHL1 and GLRA1. Expression or genetic variation of those genes are all connected to T2D pathogenesis and/or insulin secretion3,35,39, but based on our findings these results should ideally also be integrated with epigenetic marks.