The cause of PD is unknown, however, large-scale sequencing studies have compellingly identified several risk genes that have a lipid-related function, including GBA1, GALC, SMPD1, SREBF1, ELOVL7, DGKQ, ASAH1 and PLA2G61–10, with GBA1 mutations being the strongest genetic risk factor for PD. This evidence concerns the gene ASAH1 and Parkinson disease.