In the present study, IPA allowed the identification of the most important pathways activated in the maternal plasma that are potentially involved in MIAC/IAI and SPTB, including APR signaling, LXR/RXR activation, FXR/RXR activation, IL-12 signaling and production in macrophages, and primary immunodeficiency signaling. Here, NR1H4 is linked to inborn error of immunity.