Further analysis using ingenuity pathway analysis (IPA) revealed the top five canonical pathways that were mostly impacted during infection/inflammation in the amniotic cavity (Table S3): ‘acute phase response (APR) signaling’, ‘liver-X-receptor (LXR)/retinoid X receptor (RXR) activation’, ‘farnesoid X receptor (FXR)/RXR activation’, ‘IL-12 signaling and production in macrophages’, and ‘primary immunodeficiency signaling’. The gene discussed is NR1H4; the disease is infection.