TGFB1 and type 1 diabetes mellitus: Although we did not find data on this issue in the literature, the following evidence may support our finding on plasma TGFBI: 1) patients with type 1 diabetes, of which pathogenesis is involved in a low grade inflammatory process, have significantly decreased levels of TGFBI, but elevated levels of CRP and serum amyloid protein A58; 2) serum levels of TGF-β, as an inducible protein for TGFBI, were also significantly lower in women in the preterm birth group compared with controls70; and 3) TGFBI was reported to be an important negative regulator of TLR-induced inflammation71.