TNF and bacterial infectious disease: Notably, Link et al. reported that T cell-specific knockout of ADAM17 had no profound impacts on both T cell responses to bacterial infection.39 Nevertheless, despite a subtle change, the frequency of CD8+ T cells producing TNF-α and IFN-γ was increased in ADAM17 KO mice.39 Consistently, we observed similar but more prominent results using mice with T cell-specific knockout ADAM17 on the OT-I TCR transgenic background.