CD8+ T cells from WT mice were transduced with either anti-hB7-H3 CAR or anti-hB7-H3 CAR expressing an shRNA against Adam17, and adoptively transferred into tumor-bearing mice with MC38 expressing hB7-H3, without additional IL-2/sumIL-2 treatment (Fig. 6b). The gene discussed is ADAM17; the disease is neoplasm.