Surprisingly, compared to mice transferred with WT CD8+ T cells, those with ADAM17 KO CD8+ T cells had significantly reduced bacterial colonies on agar plates in both spleen and liver 4 days (Figs. 1d) and 7 days after infection (supplementary Fig. 3a), suggesting an enhanced effector function of ADAM17 deficient CD8+ T cells. The gene discussed is CD8A; the disease is infection.