By altering the total STAT3 level, a synchronized change of CXCL1 expression in NSCLC cell lines was observed in NCI-H1650 and NCI-H1675 (Figs. S4 and 5G, H), indicating that STAT3 responds to IGFBP2 and functions as a transcriptional activator of CXCL1 in NSCLC cells. The gene discussed is IGFBP2; the disease is non-small cell lung carcinoma.