BAX and infection: Bax is one of pro-apoptotic molecules and Bcl2 is one of the anti-apoptotic molecules, therefore the ratio of Bcl2/Bax represents the ability of anti-apoptosis [47].The present study reveals that the Bcl2/Bax ratio was found to be higher in the kidneys of Aim2−/− mice as compared to the control group following infection.