PTPA and experimental autoimmune encephalomyelitis: Other researches found that AIM2 negatively regulates the DNA-PK-AKT3 in microglia to control neuroinflammation [72] and enhances the stability of T regulatory cells via interacting with the RACK1-PP2A phosphatase complex to restrain AKT phosphorylation [50] in experimental autoimmune encephalomyelitis (EAE).