In contrast to upregulated DEGs, only few genes (TCEAL2, EBF1, EBF2, MAP1LC3A, ZNF429, ZNF793, ZNF248 and ZNF680) were commonly downregulated in cultured, grafted and postmortem AD neurons, all of which demonstrated relatively low expression levels in APPV717I grafts (Figure S3f, g). This evidence concerns the gene ZNF680 and Alzheimer disease.