HES1 and Alzheimer disease: While we did not identify transcriptome profiles of dedifferentiation [11], a feature also seen in directly transdifferentiated AD-induced neurons (AD iNs) [37], we observed dysregulation of some cell-cycle reentering makers in our APPV717I neurons including CDKN1A, TP53, CDK1, HES1 and REST-repressed (GAD1) gene.