Correct risk factors:• Smoking cessation (I LQE)• Avoid excess alcohol (I VLQE)• Weight reduction (I LQE)• Regular physical activity (I LQE)• Treatment of hypertension and hyperlipidaemia (I HQE)• SGLT2 inhibitors in T2DM and CVD with insufficient glycaemic control (I HQE). This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.