NT-proBNP—>125 (SR) or >365 (AF) pg/mLBNP—>35 (SR) or >105 (AF) pg/mLResting TTE—parameters indicating LV diastolic dysfunction/raised LV filling pressures:• LV mass index ≥95 (female) or ≥115 g/m2 (male)• LV relative wall thickness >0.42• LA volume index >34 (SR) or >40 mL/m2 (AF)• E/e’ ratio at rest >9• PA systolic pressure >35 mmHg• TR velocity at rest >2.8 m/s. This evidence concerns the gene NPPB and atrial fibrillation.