Correct risk factors:• Weight reduction and increased physical activity (I A)• Smoking cessation (I C)• Alcohol control (IIa C)• Treat hypertension with lifestyle changes and thiazide diuretic (I A)• Statin if CAD (I A)• SGLT2 inhibitor in T2DM and CAD (I A). The gene discussed is SLC5A2; the disease is hypertensive disorder.