Correct risk factors:• Counselling against sedentary habit, obesity, cigarette smoking, and alcohol abuse (I C)• Treatment of hypertension (I A)• Treatment with statins in patients at high risk of CVD or with CVD (I A)• SGLT2 inhibitors in patients with diabetes at high risk of CVD or with CVD (I A)• SGLT2 inhibitors in patients with T2DM and CKD (I A)• Finerenone in patients with T2DM and CKD (I A). The gene discussed is SLC5A2; the disease is Hypertension.