Correct risk factors:• Weight reduction and increased physical activity (I A)• Smoking cessation (I C)• Alcohol control (IIa C)• Treat hypertension with lifestyle changes and thiazide diuretic (I A)• Statin if CAD (I A)• SGLT2 inhibitor in T2DM and CAD (I A). This evidence concerns the gene SLC5A2 and Hypertension.