KCNH2 and malaria: Additionally,the predicted long half-life of compound 17 and the apparentlylow risk of resistance seen with compound 14 make theseries an attractive, with both these criteria being earmarked asessential for future drug candidates by the malaria research community.The SAR studies demonstrated in the manuscript would be helpful forfurther optimization of hERG inhibition of the compounds to identifya preclinical candidate from the series.