DNMT3A and cyclic hematopoiesis: Additionally, DNMT3A- and TET2-mutant CH samples showed a 3.9- and 2.9-fold increase in the rare Lin−CD34+CD38−CD45RA+ LMPP population, respectively (Figure 2H), which constitutes a minor fraction of the transcriptionally defined LMPP and multi-lymphoid progenitors (MLPs) (Figure S2D).