Interestingly, ∼70% of CH cases are associated with mutations in DNMT3A and TET2. 14,15,16,17,19,24 DNMT3A, a de novo DNA methyltransferase, catalyzes the conversion of cytosine to 5-methylcytosine (5mC), usually in CpG dinucleotides.25 Here, DNMT3A is linked to cyclic hematopoiesis.