As we have observed, both patients with psoriasis and patients with MASLD contain high numbers CD163+ macrophages, and the inflammatory response in patients with psoriasis leads to the recruitment of monocytes to the liver, exacerbating the hepatic inflammatory response and increases the incidence of MASLD and the probability of progression to NASH with increased fibrosis, and vice versa. This evidence concerns the gene CD163 and metabolic dysfunction-associated steatotic liver disease.