Blackwood EM, et al., in their study, clearly showed that the ACE2 rs2106809 T allele might be functional, down-regulating ACE2 expression and reducing promoter activity in the absence or presence of other SNPs, resulting in a decrease in the expression rate of circulating angiotensin (1–7) and contributing to an increase in blood pressure and an increased HTN susceptibility [75]. The gene discussed is ACE2; the disease is hypertensive disorder.