TARDBP and neurodegenerative disease: We also explored the influence of concomitant TDP-43 pathology in our LBD cases, given its presence in many neurodegenerative diseases.45 Among the n = 134 TDP-43 positive (TDP-43+) and n = 289 TDP-43 negative (TDP-43−) cases analysed (Supplementary Table 1), no significant DEGs were detected (Supplementary Fig. 8).