Several studies have suggested the potential role of the sex chromosomes in modulating neurodegenerative vulnerability.70-75 We observed significantly higher KDM6A expression, a gene that routinely escapes X inactivation,76 in XX females compared to XY males, and KDM6A expression has been associated with cognitive decline.76,77 Overall, our data highlights the sex-shared and sex-specific alterations in LBD and AD. The gene discussed is KDM6A; the disease is Alzheimer disease.