HAVCR2 and acute myeloid leukemia: Since Ab-dependent cell-mediated cytotoxicity (ADCC) of the anti–TIM-3 Ab on AML cells was unlikely based on the lack of efficacy against AML cells in vivo in the absence of Tc (Figure 1J), we investigated the effect of anti–TIM-3 Ab treatment on Tc phenotype in both WEHI-3B and FLT3-ITD MLL-PTD AML models.