Consistent with the potential oncogenic role of high-risk β HPV, FVBN-transgenic mice expressing HPV8 early region genes under the control of the keratin 14 (Krt14) promoter (HPV8-CERtg) exhibit skin changes mirroring human AK and spontaneously develop cSCC, which occurs with greater frequency after UV light exposure (38, 39). This evidence concerns the gene KRT14 and skin squamous cell carcinoma.