The results showed that the protective effect of LEN was totally abolished by SLC44A2 deficiency, as evidenced by unimproved aortic aneurysm incidence, aortic diameter expansion, aortic rupture rate, elastin breakage, and MMP activation in Ang II–infused Slc44a2SMKO mice treated with LEN (Supplemental Figure 13, A–H). This evidence concerns the gene AGT and aortic aneurysm.