SLC44A2 interacts with neuropilin-1 (NRP1) to activate transforming growth factor β (TGF-β) signaling in an integrin β3–dependent (ITGB3-dependent) manner, which maintains VSMCs’ contractile phenotype and alleviates aortic aneurysm. This evidence concerns the gene TGFB1 and aortic aneurysm.