By demonstrating the role of JNK-FAO-H3K9Ac axis in upregulating upd3 expression in the PCs of HSD-fed flies, the outcome of our study not only provides evidence for an alternate epigenetic mechanism by which high dietary sugar modulates gene expression in the PCs but also braids with the previous observations in providing a better understanding of high dietary sugar–induced diabetic nephropathy and cardiac dysfunction. The gene discussed is CHST3; the disease is diabetic kidney disease.