CHST3 and diabetic cardiomyopathy: Given that excessive ROS generation and oxidative stress are associated with the pathophysiology of diabetic cardiomyopathy (Kaludercic and Di Lisa, 2020), we conjectured that a further increase in the levels of ROS in the PCs could hyperactivate this signaling cascade to augment upd3 expression in the PCs of HSD-fed flies.