INS and diabetic cardiomyopathy: The increased reliance of the diabetic heart on fatty acids negatively impacts cardiac efficiency (Lopaschuk et al., 2021; Mazumder et al., 2004; Randle et al., 1963), impairs insulin metabolic signaling (Atkinson et al., 2003; Samuel and Shulman, 2016), elevates the production of ROS (Tsushima et al., 2018), increases mitochondrial membrane uncoupling, promotes lipotoxicity (Finck et al., 2002; Zhou et al., 2000), and exacerbates diabetic cardiomyopathy.