Also, NKX6.3, DLL4, SLC30A8, and STX1A, which play key roles in insulin synthesis and release [33, 36, 44], are predicted to be targeted by miR-214-5p, which was significantly upregulated in FOXA2-deficient islets, and has been previously reported to be associated with type 1 diabetes (T1D) [45]. This evidence concerns the gene DLL4 and type 1 diabetes mellitus.