Subsequently, using a subcutaneous xenograft mouse tumour model established by injecting SCC9 cells divided into NC, shEphA2, shEphA2 + OE-YAP, and shEphA2 + OE-KLF4 groups, we found that EphA2 knockdown reduced the tumour volume (Fig. 7C, D) and weight (Supplementary Fig. 6E), while YAP or KLF4 overexpression reversed these effects. Here, KLF4 is linked to neoplasm.