Increasing oxidative stress and cytosolic Cu/Zn SOD disturbance. Increasing lipid peroxidation activity in synaptosome. Increasing peroxidized lipids in the striatum and hippocampus, lactate dehydrogenase (LDH) release, and neuronal nitric oxide synthase. Upregulating IL-6. Impairing Spatial learning and memory and depression. The gene discussed is IL6; the disease is depressive disorder.