Another study indicated that a ketogenic diet, which results in elevated levels of ketones (e.g., β-hydroxybutyrate) in the blood, could prevent sleep deprivation-induced Alzheimer’s disease (AD) by inhibiting ferroptosis, and lipid peroxidation, and improving the neuronal repair ability via SIRT1/NRF2 signaling pathway (Yang et al. 2022). This evidence concerns the gene NFE2L2 and Alzheimer disease.