In support of a role of NRF2 in OSA, it has also been found that restoration of NRF2 activity can mitigate cognitive impairment and inflammation in a model of IH and sleep fragmentation by modulating ER stress and regulating the expression of the antioxidant gene Prdx1 (Qiu et al. 2023). Here, NFE2L2 is linked to Cognitive impairment.