SFTSV can infect macrophages in vivo and cause elevated both pro-inflammatory cytokines (such as IL-6 and IFN-γ) and anti-inflammatory cytokines (such as IL-10) in SFTSV-infected patients, and SFTSV infection of macrophages contributed to macrophage differentiation into the M2 phenotype (28). The gene discussed is IFNG; the disease is infection.