In a recently published animal model of coxsackievirus 3 (CVB3)-induced myocarditis in mice, colchicine improved left ventricular (LV) function, and decreased the release of troponin as well as cardiac and splenic NLRP3 inflammasome activity, without exacerbation of the viral load.24 The use of colchicine in human myocarditis remains an interesting hypothesis to be further explored in specifically designed clinical studies. The gene discussed is NLRP3; the disease is myocarditis.