Colchicine may prevent atrial fibrillation with different anti-inflammatory mechanisms: inhibition of IL-6 release and consequent fibrosis; activation of the PI3K/AKT/eNOS signalling pathway, which may reverse atrial remodelling; and reduction of NLRP3 inflammasome activity.42–44 A recent meta-analysis45 evaluated the use of colchicine in preventing atrial fibrillation in three different settings: postoperative atrial fibrillation (POAF) after cardiac surgery, atrial fibrillation recurrence following pulmonary vein ablation/isolation, and atrial fibrillation in patients with CAD. This evidence concerns the gene NLRP3 and atrial fibrillation.