Isolated tumor cells with lower Pax3::Foxo1 expression had a higher oncogenic capability in allograft models and more migratory potential in vitro, a phenomenon that is also seen for the EWSR1::FLI1 fusion in Ewing sarcoma (Franzetti et al., 2017; Seong et al., 2021). The gene discussed is FOXO1; the disease is neoplasm.