PAX3::FOXO1 inhibits the Hippo/MST1 signaling pathway, and genetic removal of Mst1/Mst2 Hippo pathway members in the Myf6-Cre Pax3::Foxo1 mouse model increased the frequency of head and neck tumors (Sahu and Mondal, 2021; Crose et al., 2014; Oristian et al., 2018). The gene discussed is FOXO1; the disease is head and neck neoplasm.