The hallmark genetic driver of ASPS is a chromosomal translocation between chromosome 17 and the X chromosome, which generates the ASPSCR1::TFE3 fusion gene (Fig. 1) (Heimann et al., 1998; Joyama et al., 1999; Mitton and Federman, 2012). Here, ASPSCR1 is linked to alveolar soft part sarcoma.