The expression of folate receptors, particularly FOLR1 and FOLR2, has been increasingly recognized as a significant factor in the development and progression of GC [13,14]. These receptors, which are overexpressed in various malignancies, including GC, mediate the cellular uptake of folate, a B vitamin essential for DNA synthesis, repair, and methylation [15,16]. The gene discussed is FOLR1; the disease is gastric cancer.