Specifically, the Erb-b2 receptor tyrosine kinase 3 (ERBB3) gene, Tyrosine kinase 2 (TYK2) gene, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (ATP2A1) gene, Interleukin-27 (IL-27) geneand Lymphotoxin β (LT- β) gene overexpression is negatively correlated with the risk of developing T1DM (OR values all<1). The gene discussed is IL27; the disease is type 1 diabetes mellitus.