Similar U-shaped associations for AIP have been reported in other diseases; in a study on the adverse prognosis of acute ischemic stroke patients (52), Liu H and colleagues found a U-shaped association between AIP quartiles (Q1-Q4) and 3-month mortality in stroke patients, with the lowest mortality risk associated with AIP values between -0.1 and 0.08. The gene discussed is AIP; the disease is stroke disorder.