Moreover, targeted treatments such as MitoQ10 supplementation (68) and melatonin supplementation acting via the SIRT3–SOD2-dependent mechanism (59) demonstrate the potential to reverse endocrine abnormalities, reduce oxidative stress, and improve mitochondrial function, consequently ameliorating obesity-induced reproductive defects and promoting oocyte developmental potential. Here, SIRT3 is linked to obesity due to melanocortin 4 receptor deficiency.