The use of gold nanoparticles (AuNPs) to deliver an miR-326 mimic is an effective method to suppress the PDK1/AKT/c-myc axis and regulate many processes such as invasion, migration, apoptosis, and epithelial-mesenchymal transition (EMT) in HCC (Mo et al., 2019). Here, PDK1 is linked to hepatocellular carcinoma.