CCR7 and neoplasm: We have previously shown that integrins and integrin-regulated BM-DC epigenetic reprogramming regulate BM-DC anti-tumor responses through a CCR7-dependent mechanism.18 As we show here that partially suppressing BM-DC glycolytic metabolism leads to BM-DC activation (increased cytokine responses, CCR7 expression, migration speed, and T cell activation potential), we decided to explore the effect of 2DG-induced metabolic stress in BM-DCs on tumor growth in vivo.