Deng et al. (2020) showed that ROCK2 could promote the proliferation of osteosarcoma cells. Overexpression of ROCK2 promotes OGT protein stability by inhibiting OGT degradation and ubiquitination through the ubiquitin-proteasome system, which ultimately promotes osteosarcoma cell proliferation and tumor growth and increases resistance to TRAIL (Deng et al., 2020). In addition, Sun et al. (2022) showed that lncEBLN3P was able to enhance OGT expression by targeting miR-200a-3p, which ultimately promotes metastasis and drug resistance in osteosarcoma. This evidence concerns the gene ROCK2 and osteosarcoma.