OXT and obesity due to melanocortin 4 receptor deficiency: External variables such as obesity in rats (Krskova et al., 2020) and drugs like paracetamol and benzodiazepines, which may be able to mimic oxytocin functions by alleviating anxiety and pain, therefore decreasing oxytocin because of its function being fulfilled, may also impact pain perception in prairie voles and SD rats (Ruginsk et al., 2010; Stevenson et al., 2017; Kandis et al., 2018).