Oxytocin could offer heart protection from dietary problems, help the regeneration of multiple tissues, and both directly and indirectly reduce obesity, through portion control both in humans [in the hedonic (pleasure-related) and homeostatic (energy balance-related) aspects of feeding] and animals (Espinoza et al., 2021; Mitsui et al., 2011; Yokoyama et al., 2009; Anekonda et al., 2021; Head et al., 2019; Nakamura et al., 2011; Gosnell and Levine, 2009; Lohmeier et al., 2003; Shimizu et al., 2016; Skinner et al., 2019; Yao et al., 2022). Here, OXT is linked to obesity due to melanocortin 4 receptor deficiency.