Protein aggregation of tau, amyloid beta peptide, α-synuclein, and TAR DNA binding protein 43 (TDP-43) represent well-characterized drivers of diverse proteinopathy disorders associated with dementia that include Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD) [5–7]. The gene discussed is APP; the disease is Alzheimer disease.