Recently, due to advances in cryogenic electron microscopy (cryo-EM) previously unidentified, cytoplasmic protein aggregates in the brains of a diverse range of neurodegenerative diseases including FTLD, DLB, progressive supranuclear palsy (PSP), and PD were discovered to be homotypic aggregates of the C-terminal fragment of TMEM106B localized to the cytosol [12–16]. The gene discussed is TMEM106B; the disease is Parkinson disease.