Recently, due to advances in cryogenic electron microscopy (cryo-EM) previously unidentified, cytoplasmic protein aggregates in the brains of a diverse range of neurodegenerative diseases including FTLD, DLB, progressive supranuclear palsy (PSP), and PD were discovered to be homotypic aggregates of the C-terminal fragment of TMEM106B localized to the cytosol [12–16]. This evidence concerns the gene TMEM106B and Classical progressive supranuclear palsy.