TMEM106B and supranuclear palsy, progressive, 1: Recently, due to advances in cryogenic electron microscopy (cryo-EM) previously unidentified, cytoplasmic protein aggregates in the brains of a diverse range of neurodegenerative diseases including FTLD, DLB, progressive supranuclear palsy (PSP), and PD were discovered to be homotypic aggregates of the C-terminal fragment of TMEM106B localized to the cytosol [12–16].