CACNA2D2 and Epileptic encephalopathy: Leveraging organism phenotype data proves to be an important step in the context of functional validation, as demonstrated by Pippucci et al., who used Exomiser to enhance the prioritisation of candidate genes in a case of epileptic encephalopathy, ultimately identifying a previously undiscovered mutation in CACNA2D2 to be causative of the disease [31].