Unlike the acute GVHD model in which F1 B cells are most profoundly affected, in D2→F1 mice the percentage increase over control was highest at both doses for F1 CD4 T cells (>200%), followed in descending order by F1 CD11c+ DCs, CD11b+ macrophages, B cells and CD8 T cells (Table 2A). The gene discussed is CD8A; the disease is graft versus host disease.