CD4 and Autoimmunity: In line with findings described here, females will be at greater risk for humoral autoimmunity in this scenario, due to their propensity for heightened antibody responses relative to males, coupled with a greater tendency for CD4 T cell expansion and skewing towards Tfh cells as seen in D2 GVHD mice (Figs 2C, 2H, 5E,H).