Zuo et al., 2022 demonstrated that EXD upregulated glucocorticoid receptor (GR) and downregulated GR (Nr3c1) and glutamate metabotropic receptor 5 (GRM5) in the amygdala of the depression mouse model. She et al., 2021 demonstrated that EXD upregulated the expression of GR in the hippocampus of the MS-RS-induced depression mouse model. This evidence concerns the gene GRM5 and major depressive disorder.