Liang et al., 2023 demonstrated that EXD significantly enhanced the protein and mRNA levels of BDNF, TrkB, and CREB in the hippocampus of the MS-RS-induced depression mouse model. Additionally, Zhang et al. (2021a) utilized ovariectomy combined with CUMS to establish a mouse model of menopausal depression and demonstrated that EXD upregulated the BDNF levels in the hippocampus of the perimenopausal depression mouse model. This evidence concerns the gene CREB1 and major depressive disorder.