NLRP3 and autoimmune disease: In the meta-analysis conducted by Wu et al., the effects of NLRP3 rs10754558 and rs35829419 polymorphisms on autoimmune diseases was investigated, and also a significant protective effect of the rs35829419 variant on rheumatoid arthritis (RA) but not overall autoimmune diseases was observed.  In addition, rs10754558 polymorphism significantly decreased the risk of this disease only in Latin Americans.